How does a normal cell turn into a deadly cancer? Seeking an answer to this Question researchers examined the tumor genomes of nearly 300 prostate cancer patients. Their findings describe the ways in which changes in the prostate cells' genetic information pave the way for cancer development. Using a newly developed computer model, it is now possible to […]
Researchers recently discovered that by testing the level of NER (nucleotide excision repair) gene expression, pediatric oncologists can determine the likelihood of early relapse (less than three years) in their acute lymphoblastic leukemia (ALL) patients.
Exercise has been touted to build bone mass, but exactly how it actually accomplishes this is a matter of debate. Now, researchers show that an exercise-induced hormone activates cells that are critical for bone remodeling in mice. A study identifies a receptor for irisin, an exercise hormone, and shows that irisin impacts sclerostin in mice, a major cellula […]
NK cells, or natural killer cells, play an important role in the body's defences against cancer and various infections. Now scientists have mapped how the different steps of the maturation process of these supercells from blood producing stem cells in the bone marrow are regulated: knowledge which is crucial for the development of new immunotherapies ag […]
A new compound that targets a receptor within sarcoma cancer cells shrank tumors and hampered their ability to spread in mice and pigs, a study reports. The researchers conducted a multi-year, cross-disciplinary study that went from screening potential drug candidates to identifying and synthesizing one compound, to packaging it into nanoparticles for delive […]