Childhood experience of parental cancer is linked to poorer school grades, educational attainment, and subsequent earning power as a young adult, suggests a data linkage study of more than one million Danes.
A new scale for tumor DNA mutations which will simplify and standardize choices for targeted cancer treatment has been agreed by leading cancer specialists in Europe and North America. The scale, called ESCAT (ESMO Scale for Clinical Actionability of molecular Targets), aims to optimize patient care by making it easier to identify patients with cancer who ar […]
A blood test can predict which patients with a type of cancer called diffuse large B cell lymphoma are likely to respond positively to initial therapy and which are likely to need more aggressive treatment, according to a multicenter study.
Scientists have identified two molecules, Sprouty 1 and Sprouty 2, that modify the survival of effector T cells and the development of memory CD8 T cells. Their findings offer promising potential for immunotherapeutic strategies to combat cancer and chronic infections.
Chronic active Epstein-Barr virus infection (CAEBV) is an inflammatory disorder with potential for tumor development. Here, unusual phosphorylation was observed on STAT3 in EBV-infected T- or NK-cells from patients with CAEBV. Researchers found that ruxolitinib, a drug that is currently used for treatment of myelofibrosis and polycythemia vera, could suppres […]
Researchers have uncovered a molecular mechanism behind one of biology's long-standing mysteries: why individuals carrying identical gene mutations for a disease end up having varying severity or symptoms of the disease. The study has exciting implications for future prediction of the severity of serious diseases such as cancer and autism spectrum disor […]