A multidisciplinary team of researchers have developed an anti-inflammatory drug molecule with a new mechanism of action. By inhibiting a certain protein, the researchers were able to reduce the signals that trigger an inflammation.
Researchers investigating new treatments for neuroblastoma -- one of the most common childhood cancers -- have found that a combination of two drugs made tumors disappear in mice, making it more effective than any other drugs tested in these animals.
Pancreatic cancer cells are known for their ability to thrive under extreme conditions of low nutrients and oxygen, a trait known in the cancer field as 'austerity.' The cells' remarkable resistance to starvation is one reason why pancreatic cancer is so deadly. Now researchers have identified a compound from a Congolese plant that has strong […]
Scientists have successfully engineered novel DNA-encoded monoclonal antibodies (DMAbs) targeting Zaire Ebolavirus that were effective in preclinical models. Study results showed that DMAbs were expressed over a wide window of time and offered complete and long-term protection against lethal virus challenges. DMAbs may also provide a novel powerful platform […]
Old age is the greatest risk factor for many diseases, including Alzheimer's disease (AD) and cancer. Geroprotectors are a recently identified class of anti-aging compounds. New research has now identified a unique subclass of these compounds, dubbed geroneuroprotectors (GNPs), which are AD drug candidates and slow the aging process in mice.
Scientists paired drug-delivering nanoparticles like dance partners to reveal that molecules attach to targets on cells differently based upon their position in time. The discovery could improve methods for screening drugs for therapeutic effectiveness.