When the HLF (hepatic leukemia factor) gene -- which is expressed in immature blood cells -- does not shut down on time, we are unable to develop a functional long-term immune system, investigators have found. This could be a very early stage of leukemia, they say.
The environment surrounding a tumor can trigger metastatic behavior in cancer cells, a team of bioengineers and bioinformaticians has discovered. Specifically, when tumor cells are confined in a dense environment, the researchers found that they turn on a specific set of genes and begin to form structures that resemble blood vessels.
Scientists have engineered a mouse model to study a rare and often-fatal form of liver cancer. They've used it to clarify what drives these tumors at the molecular level, and discover new drug concepts.