The enzyme ribonucleotide reductase is a bottleneck for cancer cell growth. Scientists have identified a way of targeting ribonucleotide reductase that may avoid the toxicity of previous approaches, informing focused drug discovery efforts.
In a study using yeast cells and data from cancer cell lines, scientists report they have found a potential weak spot among cancer cells that have extra sets of chromosomes, the structures that carry genetic material. The vulnerability, they say, is rooted in a common feature among cancer cells -- their high intracellular protein concentrations -- that make […]
A bone cancer known as osteosarcoma is genetically similar in dogs and human children, according to the results of a new study. The findings could help break the logjam in the treatment of this deadly disease, which hasn't seen a significant medical breakthrough in nearly three decades.